Edwards began caddying for Watson in 1973 and worked with him until 1989. Edwards left to assist Greg Norman but returned to Watson's side in 1992 and stayed until 2003. That year, he was diagnosed with amyotrophic lateral sclerosis (commonly known as Lou Gehrig's disease) but continued to caddie for Watson until the strain became too much.
His life is chronicled in Caddie For Life: The Bruce Edwards Story (ISBN 0316777889) written by his biographer John Feinstein.
Edwards succumbed to ALS at his home in Ponte Vedra Beach, Florida at age 49.